Crouch M F, Morris C P, Cheah T B, Rush R A
Brain Res. 1982 Jan 28;232(1):212-5. doi: 10.1016/0006-8993(82)90628-x.
The radioligand [3H]quinuclidinyl benzilate has been used to examine the muscarinic receptor population of the chick expansor secundariorum muscle during its post-hatch development. At hatch the muscle bound 0.165 fmol of the ligand, but during the following two weeks binding decreased rapidly. Further reduction in ligand binding to the adult stage was observed, but at a much slower rate. The developmental loss of binding sites within this tissue corresponds to previously demonstrated reduction in acetylcholine sensitivity.
放射性配体[3H]樟柳碱已被用于研究雏鸡次级扩张肌在孵化后发育过程中的毒蕈碱受体群体。在孵化时，该肌肉结合了0.165 fmol的配体，但在接下来的两周内，结合迅速减少。观察到配体与成年阶段的结合进一步减少，但速度要慢得多。该组织内结合位点的发育性丧失与先前证明的乙酰胆碱敏感性降低相对应。
