雌激素和催乳素对黑质及纹状体谷氨酸脱羧酶活性的比较作用。
Comparative effects of estrogens and prolactin on nigral and striatal GAD activity.
作者信息
Nicoletti F, Patti F, Ferrara N, Canonico P L, Giammona G, Condorelli D F, Scapagnini U
出版信息
Brain Res. 1982 Jan 28;232(1):238-41. doi: 10.1016/0006-8993(82)90633-3.
The comparative effects of a 10 day estrogen treatment and estrogen independent hyperprolactinemia on nigral and striatal glutamic acid decarboxylase (GAD, EC 4.1.1.15) activity were investigated in male rats. Data obtained show that estrogen treatment decreases GAD activity in substantia nigra, while an increase was observed in conditions of hyperprolactinemia induced by adenohypophysis homograft or acute and chronic sulpiride injection. The possibility of an opposite modulation of strio-nigral GABAergic system by estrogens and prolactin is suggested.
在雄性大鼠中研究了为期10天的雌激素治疗和雌激素非依赖性高催乳素血症对黑质和纹状体谷氨酸脱羧酶（GAD，EC 4.1.1.15）活性的比较作用。获得的数据表明，雌激素治疗会降低黑质中的GAD活性，而在垂体同种异体移植或急性和慢性注射舒必利诱导的高催乳素血症情况下则观察到活性增加。提示雌激素和催乳素对纹状体 - 黑质GABA能系统存在相反的调节作用。
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