Staines W A, Benjamin A M, McGeer E G
J Neurosci Res. 1980;5(6):555-62. doi: 10.1002/jnr.490050610.
The distribution of cysteinesulfinic acid decarboxylase (CSAD) activity has been studied for some time on the assumption that this activity was a marker for taurine-containing structures in the CNS. We have found that various in vivo and in vitro treatments of CNS tissues result in parallel changes in the activities of CSAD and glutamic acid decarboxylase (GAD). This suggests that the assay for CSAD is in fact measuring predominantly GAD activity. This hypothesis is tested by lesion, regional distribution, kinetic, inhibitor, and stability studies.
一段时间以来，人们一直在研究半胱氨酸亚磺酸脱羧酶（CSAD）活性的分布情况，假设这种活性是中枢神经系统中含牛磺酸结构的一个标志物。我们发现，对中枢神经系统组织进行的各种体内和体外处理会导致CSAD和谷氨酸脱羧酶（GAD）活性发生平行变化。这表明CSAD检测实际上主要测量的是GAD活性。通过损伤、区域分布、动力学、抑制剂和稳定性研究对这一假设进行了检验。
