Heyer E J, Nowak L M, Macdonald R L
Brain Res. 1982 Jan 28;232(1):41-56. doi: 10.1016/0006-8993(82)90609-6.
The convulsant compounds bicuculline (BICUC) and penicillin (PCN) are antagonists of GABA-mediated synaptic inhibition. In addition, we have shown that BICUC and PCN produced membrane depolarization of mouse spinal cord neurons in primary dissociated cell culture by blocking a potassium conductance, a non-synaptic direct effect. Both compounds also prolonged calcium-dependent action potentials of mouse dorsal root ganglion and spinal cord neurons in cell culture. Thus, BICUC and PCN had both synaptic and non-synaptic actions. The possibility that both synaptic and non-synaptic actions of BICUC and PCN are involved in their convulsant mechanism of action is discussed.
惊厥性化合物荷包牡丹碱（BICUC）和青霉素（PCN）是γ-氨基丁酸（GABA）介导的突触抑制的拮抗剂。此外，我们已经表明，BICUC和PCN通过阻断钾离子电导（一种非突触直接效应），在原代解离细胞培养中使小鼠脊髓神经元发生膜去极化。这两种化合物还延长了细胞培养中小鼠背根神经节和脊髓神经元的钙依赖性动作电位。因此，BICUC和PCN具有突触和非突触作用。本文讨论了BICUC和PCN的突触和非突触作用均参与其惊厥作用机制的可能性。
