Jones R M, Hill A B, Nahrwold M L, Tait A R
Can Anaesth Soc J. 1982 Jan;29(1):65-7. doi: 10.1007/BF03007951.
The anaesthetized, heparinized health adult dogs were infused with protamine sulphate 3 mg X kg-1 and plasma ionized calcium was measured. A significant (p less than 0.01) decrease in ionized calcium occurred which preceded the maximal reduction in cardiac output and systemic arterial pressure. The clinical implications of these results are discussed.
