肝素与鱼精蛋白对犬左心室功能的影响。

Effects of heparin and protamine on left ventricular performance in the dog.

作者信息

Marin-Neto J A, Sykes M K, Marin J L, Orchard C, Chakrabarti M K

出版信息

Cardiovasc Res. 1979 May;13(5):254-9. doi: 10.1093/cvr/13.5.254.

DOI:10.1093/cvr/13.5.254

Abstract

The effects of protamine on left ventricular (LV) function were measured under conditions of controlled heart rate and proximal aortic pressure in eight anaesthetized, heparinised dogs. Protamine 3 mg.kg-1 produced a 21% decrease in LV dP/dt max, a 43% decrease in cardiac output, a 47% decrease in stroke work and decreases in systolic and diastolic pressures (-16%, -19% respectively). Protamine 6 mg.kg-1 resulted in a 17% decrease in LV dP/dt max, a 26% decrease in cardiac output, a 50% decrease in LV stroke work and 25 and 30% decreases in systolic and diastolic pressures. These results show that an impairment of LV function plays an important part in the circulatory depression produced by protamine.

摘要

在八只麻醉、肝素化的狗身上，于心率和近端主动脉压力受控的条件下测量了鱼精蛋白对左心室（LV）功能的影响。3mg·kg-1的鱼精蛋白使左心室最大dp/dt降低21%，心输出量降低43%，每搏功降低47%，收缩压和舒张压降低（分别为-16%、-19%）。6mg·kg-1的鱼精蛋白使左心室最大dp/dt降低17%，心输出量降低26%，左心室每搏功降低50%，收缩压和舒张压降低25%和30%。这些结果表明，左心室功能受损在鱼精蛋白所致的循环抑制中起重要作用。