Bichler E, Daxenbichler G
Cancer. 1982 Feb 15;49(4):619-22. doi: 10.1002/1097-0142(19820215)49:4<619::aid-cncr2820490402>3.0.co;2-v.
In some squamous cell carcinomas of the otorhinolaryngologic region with different grades of differentiation, a protein was found that specifically binds vitamin A acid. In 28 of 37 tumors, the retinoic acid-binding sites were found in significant amounts, according to the authors' data. Areas with metastases showed a lower incidence of retinoic acid-binding, whereas in all normal epiglottis and vocal cord tissue specimens the binding was present. The possible significance of the protein-binding for the biologic effect of the vitamin A acid is discussed.
在一些不同分化程度的耳鼻咽喉区域鳞状细胞癌中，发现了一种能特异性结合视黄酸的蛋白质。根据作者的数据，在37个肿瘤中的28个中发现了大量的视黄酸结合位点。有转移的区域视黄酸结合的发生率较低，而在所有正常会厌和声襞组织标本中均存在这种结合。文中讨论了这种蛋白质结合对视黄酸生物学效应的可能意义。
