Malý J, Schück O
Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
Int J Clin Pharmacol Ther Toxicol. 1990 Oct;28(10):443-5.
The results of a study investigating the effect of single oral administration of B (benzbromarone), and a combination of B + H (hydrochlorothiazide), in 10 healthy volunteers suggest the following conclusions: 1) In agreement with literary data, B at a dose of 100 mg has a significant hypouricemic effect with a 39% decrease after 6 h, and a 53% decrease after 24 h. 2) B and B + H significantly enhance renal clearance and fractional excretion of uric acid but there was no demonstrable significant inverse relation between these parameters and the plasma level of uric acid. 3) B affects PUA (plasma concentration of uric acid) also by some extrarenal action which is not related to the pre-existing alteration of uric acid metabolism. 4) Simultaneous single administration of B + H does not reduce the effect of B on renal excretion and on the plasma level of uric acid. 5) A single dose of B causes a slight but significant decrease in fractional potassium excretion without any demonstrable effect on fractional excretion of sodium and that of all osmotically active substances.
一项针对10名健康志愿者进行的关于单次口服B（苯溴马隆）以及B + H（氢氯噻嗪）组合效果的研究结果表明以下结论：1）与文献数据一致，100毫克剂量的B具有显著的降尿酸作用，6小时后尿酸降低39%，24小时后降低53%。2）B以及B + H显著提高尿酸的肾清除率和排泄分数，但这些参数与尿酸血浆水平之间未显示出明显的显著负相关关系。3）B还通过一些与尿酸代谢原有改变无关的肾外作用影响尿酸血浆浓度（PUA）。4）同时单次给予B + H不会降低B对肾脏排泄和尿酸血浆水平的影响。5）单次剂量的B导致钾排泄分数略有但显著降低，而对钠和所有渗透活性物质的排泄分数没有任何明显影响。
