14α-乙基-5α-胆甾-7-烯-3β,15α-二醇是一种有效的甾醇生物合成抑制剂，在培养的哺乳动物细胞中有两个作用位点。 - Suppr | 超能文献

14 alpha-Ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol, a potent inhibitor of sterol biosynthesis, has two sites of action in cultured mammalian cells.

作者信息

Pinkerton F D, Izumi A, Anderson C M, Miller L R, Kisic A, Schroepfer G J

出版信息

J Biol Chem. 1982 Feb 25;257(4):1929-36.

Abstract

摘要

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1

14 alpha-Ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol, a potent inhibitor of sterol biosynthesis, has two sites of action in cultured mammalian cells.14α-乙基-5α-胆甾-7-烯-3β,15α-二醇是一种有效的甾醇生物合成抑制剂，在培养的哺乳动物细胞中有两个作用位点。

J Biol Chem. 1982 Feb 25;257(4):1929-36.

2

Inhibitors of sterol synthesis. Chemical syntheses, properties and effects of 4,4-dimethyl-15-oxygenated sterols on sterol synthesis and on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells.甾醇合成抑制剂。4,4-二甲基-15-氧化甾醇在培养的哺乳动物细胞中对甾醇合成及3-羟基-3-甲基戊二酰辅酶A还原酶活性的化学合成、性质及作用。

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3

Inhibitors of sterol biosynthesis. Synthesis and activities of ring C oxygenated sterols.固醇生物合成抑制剂。C环氧化固醇的合成与活性。

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4

Inhibitors of sterol synthesis. Chemical synthesis of 5 beta-cholest-8-ene-3 beta,15 alpha-diol and its effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.固醇合成抑制剂。5β-胆甾-8-烯-3β,15α-二醇的化学合成及其对CHO-K1细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的影响。

J Lipid Res. 1989 Jun;30(6):919-28.

5

Inhibitors of sterol synthesis. Differential effects of 14 alpha-hydroxymethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol and 14 alpha-hydroxymethyl-5 alpha-cholest-6-ene-3 beta, 15 alpha-diol on sterol synthesis in cell-free homogenates of rat liver.固醇合成抑制剂。14α-羟甲基-5α-胆甾-7-烯-3β,15α-二醇和14α-羟甲基-5α-胆甾-6-烯-3β,15α-二醇对大鼠肝脏无细胞匀浆中固醇合成的不同影响。

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6

Inhibition of sterol biosynthesis in animal cells by 14 alpha-alkyl-substituted 15-oxygenated sterols.14α-烷基取代的15-氧化甾醇对动物细胞中甾醇生物合成的抑制作用。

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7

Inhibitors of sterol synthesis. Submicromolar 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol causes a major modification of the sterol composition of CHO-K1 cells and a marked change in cell morphology.固醇合成抑制剂。亚微摩尔浓度的14α-乙基-5α-胆甾-7-烯-3β,15α-二醇会导致CHO-K1细胞的固醇组成发生重大改变，并使细胞形态发生显著变化。

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8

15 beta-Methyl-5 alpha,14 beta-cholest-7-ene-3 beta,15 alpha-diol. Synthesis, structure, and inhibition of sterol synthesis in animal cells.15β-甲基-5α,14β-胆甾-7-烯-3β,15α-二醇。动物细胞中甾醇合成的合成、结构及抑制作用

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9

Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.固醇合成抑制剂。3β-羟基-5α-胆甾-8(14)-烯-15-酮的代谢产物(25R)-3β,26-二羟基-5α-胆甾-8(14)-烯-15-酮的化学合成、结构及生物活性

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10

Inhibition of sterol biosynthesis by 9 alpha-fluoro and 9 alpha-hydroxy derivatives of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.5α-胆甾-8(14)-烯-3β-醇-15-酮的9α-氟和9α-羟基衍生物对甾醇生物合成的抑制作用

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引用本文的文献

1

5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.5α-胆甾-8(14)-烯-3β-醇-15-酮，一种有效的甾醇生物合成抑制剂，可降低狒狒的血清胆固醇并改变脂蛋白中胆固醇的分布。

Proc Natl Acad Sci U S A. 1982 May;79(9):3042-6. doi: 10.1073/pnas.79.9.3042.

2

5 alpha-Cholest-8(14)-en-3 beta-ol-15-one lowers serum cholesterol and induces profound changes in the levels of lipoprotein cholesterol and apoproteins in monkeys fed a diet of moderate cholesterol content.5α-胆甾-8(14)-烯-3β-醇-15-酮可降低血清胆固醇，并使喂食中等胆固醇含量饮食的猴子的脂蛋白胆固醇和载脂蛋白水平发生显著变化。

Proc Natl Acad Sci U S A. 1984 Nov;81(21):6861-5. doi: 10.1073/pnas.81.21.6861.