5α-胆甾-8(14)-烯-3β-醇-15-酮，一种有效的甾醇生物合成抑制剂，可降低狒狒的血清胆固醇并改变脂蛋白中胆固醇的分布。
5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.
作者信息
Schroepfer G J, Parish E J, Kisic A, Jackson E M, Farley C M, Mott G E
出版信息
Proc Natl Acad Sci U S A. 1982 May;79(9):3042-6. doi: 10.1073/pnas.79.9.3042.
Abstract
5 alpha-Cholest-8(14)-en-3 beta-0l-15-one has been found to have significant hypocholesterolemic action on oral administration to baboons at dosages of 50 and 75 mg/kg of body weight. The 15-ketosterol decreased the levels of total serum cholesterol and low density lipoprotein plus very low density lipoprotein (LDL/VLDL) cholesterol and the percentage of total cholesterol associated with LDL/VLDL and increased the percentage of total cholesterol associated with high density lipoprotein (HDL). Moreover, administration of the steroid was associated with an absolute increase in the concentration of HDL cholesterol in those animals with low HDL levels (or with a low percentage of total serum cholesterol in the HDL fraction.
摘要
已发现5α-胆甾-8(14)-烯-3β-醇-15-酮以50和75毫克/千克体重的剂量口服给予狒狒时具有显著的降胆固醇作用。这种15-酮甾醇降低了血清总胆固醇水平以及低密度脂蛋白加极低密度脂蛋白（LDL/VLDL）胆固醇水平，以及与LDL/VLDL相关的总胆固醇百分比，并增加了与高密度脂蛋白（HDL）相关的总胆固醇百分比。此外，在那些HDL水平低（或HDL部分中总血清胆固醇百分比低）的动物中，给予该类固醇与HDL胆固醇浓度的绝对增加有关。
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5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.5α-胆甾-8(14)-烯-3β-醇-15-酮，一种有效的甾醇生物合成抑制剂，可降低狒狒的血清胆固醇并改变脂蛋白中胆固醇的分布。
Proc Natl Acad Sci U S A. 1982 May;79(9):3042-6. doi: 10.1073/pnas.79.9.3042.
2
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