Ecknauer R, Vadakel T, Wepler R
J Gerontol. 1982 Mar;37(2):151-5. doi: 10.1093/geronj/37.2.151.
Age-related changes in the gut were investigated in male gnotobiotic rats, living in a controlled and constant environment until death. Parameters of the regenerative compartment of the jejunum and ileum were the cell production rate (measured by a stathmokinetic technique), the number of crypts, and the crypt:villus ratio. Parameters of the functional compartment were the average surface area of the villi, height and broadness of villi, etc. Age did not change the size of individual villi or crypts or the cell production rate. The number of crypts and, to the same extent, the number of villi increased with age, indicating a continuation of mucosal growth up to an age of 2 yr.
在无菌雄性大鼠中研究了肠道随年龄的变化，这些大鼠生活在可控的恒定环境中直至死亡。空肠和回肠再生区的参数包括细胞产生率（通过有丝分裂动力学技术测量）、隐窝数量以及隐窝与绒毛比例。功能区的参数包括绒毛的平均表面积、绒毛高度和宽度等。年龄并未改变单个绒毛或隐窝的大小或细胞产生率。隐窝数量以及在相同程度上绒毛数量随年龄增加，表明黏膜生长持续到2岁。
