Williams G T
J Pathol. 1982 Jan;136(1):15-25. doi: 10.1002/path.1711360103.
Isolated epithelial cells from disaggregated rat BCG granulomas show a morphological spectrum from "plasmacytoid" to "vesicular" froms on electron microscopy. Functional studies on these isolated cells showed that all epithelial cells exhibited poor trypsin-resistant glass adherence and poor phagocytosis of latex, zymosan, antibody coated and complement coated and complement coated erythrocytes when compared with macrophages, especially at the vesicular end of the spectrum. A high proportion of all epithelioid cell types was found to have Fc surface receptors but C3 receptors were reduced on vesicular cells compared with the plasmacytoid variety. The findings indicate that the progressive transformation of mononuclear phagocytes into vesicular epithelioid cells through plasmacytoid intermediates is accompanied by a concomitant modification of cell function. The significance of these changes is discussed.
从分散的大鼠卡介苗肉芽肿中分离出的上皮细胞，在电子显微镜下呈现出从“浆细胞样”到“泡状”的形态谱。对这些分离细胞的功能研究表明，与巨噬细胞相比，所有上皮细胞对胰蛋白酶抗性玻璃的黏附性较差，对乳胶、酵母聚糖、抗体包被和补体包被的红细胞的吞噬作用也较差，尤其是在谱线的泡状末端。发现所有上皮样细胞类型中很大一部分具有Fc表面受体，但与浆细胞样细胞相比，泡状细胞上的C3受体减少。这些发现表明，单核吞噬细胞通过浆细胞样中间体逐渐转化为泡状上皮样细胞的过程中，细胞功能也随之发生改变。讨论了这些变化的意义。
