Gifford R W
JAMA. 1982 Feb 12;247(6):781-5.
Although systolic hypertension in the elderly has received limited attention, it is associated with increased mortality and morbidity; its is not clear, however, whether it is the elevated blood pressure or the arteriosclerosis, for which it is a marker, that increases the risk. While there are no controlled, prospective trials confirming a reduction in morbidity and mortality with treatment, reduction of the systolic blood pressure will reduce diagnosis of systolic hypertension is clearly established by multiple determinations. Contrary to the opinion of some, the elderly are able to tolerate antihypertensive drugs well when the drugs are administered cautiously in low dosages initially, with small increments.
尽管老年收缩期高血压受到的关注有限，但它与死亡率和发病率的增加有关；然而，尚不清楚是血压升高还是作为其标志的动脉硬化增加了风险。虽然没有对照的前瞻性试验证实治疗能降低发病率和死亡率，但多次测定清楚地表明，降低收缩压会减少收缩期高血压的诊断。与一些人的观点相反，当初始以低剂量谨慎给药并小幅增量时，老年人能够很好地耐受抗高血压药物。
