Chan S H, Yeo P P, Lui K F, Wee G B, Woo K T, Lim P, Cheah J S
Tissue Antigens. 1978 Aug;12(2):109-14. doi: 10.1111/j.1399-0039.1978.tb01306.x.
HLA locus A and B typing was performed on 86 Chinese thyrotoxicosis (Graves' Disease) patients and 238 normal Chinese subjects. The frequency of HLA-Bw46 (Sin 2) was found to be significantly higher among the patients than controls (x2 = 26.15, corrected P less than .003, relative risk = 3.74). The risk associated with Bw46 was reflected in the Bw46 heterozygotes. The relative risks of the joint occurrence of Bw46/B40 and Bw46/B13 were 8.74 and 5.88 respectively.
对86例中国甲状腺毒症（格雷夫斯病）患者和238名正常中国受试者进行了HLA基因座A和B分型。发现患者中HLA - Bw46（Sin 2）的频率显著高于对照组（x2 = 26.15，校正P小于0.003，相对风险 = 3.74）。与Bw46相关的风险在Bw46杂合子中有所体现。Bw46/B40和Bw46/B13联合出现的相对风险分别为8.74和5.88。
