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Japanese Graves' disease: association with HLA-Bw46.

作者信息

Naito S, Sasaki H, Arakawa K

机构信息

Department of Internal Medicine, Fukuoka University Medical School, Japan.

出版信息

Endocrinol Jpn. 1987 Oct;34(5):685-8. doi: 10.1507/endocrj1954.34.685.

DOI:10.1507/endocrj1954.34.685
PMID:3436299
Abstract

HLA-A, -B, and -C antigen frequency of 61 Japanese patients with Graves' disease, and HLA-DR and -DQ frequency of 53 patients with it were compared that of 1,998 controls. The prevalence of Bw46 was significantly higher in patients with Graves' disease (23.0% vs 8.4%, Pc less than 0.003). The result was quite different from previous reports on Japanese Graves' disease.

摘要

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The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.
基因间重组的HLA-B∗46:01具有独特的肽组,其中包括KIR2DL3配体。
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The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C.基因座间重组的HLA-B*4601在肽结合方面具有高选择性,并具有HLA-C的功能特征。
J Exp Med. 1996 Aug 1;184(2):735-40. doi: 10.1084/jem.184.2.735.