An investigation of DNA-repair phenomena induced by 4-chloromethylbiphenyl (4CMB).

The ability of 4CMB to induce repair phenomena has been investigated in 3 types of assay. No significant unscheduled DNA synthesis or repair replication was found, although the compound gave a weakly positive dose-related response in strand-break assays, with 250 microgram/ml producing significant amounts of strand breaks. These data indicate that 4CMB is a weakly genotoxic agent.