用4-氯甲基联苯和苄基氯处理的人淋巴细胞的中期分析。
Metaphase analysis of human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride.
作者信息
Kirkland D J, Smith K L, Jenkinson P C
出版信息
Mutat Res. 1982 Jan-Feb;100(1-4):297-9. doi: 10.1016/0165-1218(82)90064-7.
PMID:7057764
Abstract
4CMB and BC caused mitotic inhibition in human lymphocytes at low doses (greater than 20 and greater than 10 microgram/ml respectively). At non-inhibitory concentrations, neither substance produced increases in cells with breaks or breaks per cell, although 4CMB did induce a significant increase in gaps at dose. 4CMB and BC are not chromosome mutagens in this system.
摘要
4 - 氯 - 邻甲苯胺（4CMB）和苄基氯（BC）在低剂量时（分别大于20微克/毫升和大于10微克/毫升）会导致人淋巴细胞有丝分裂抑制。在非抑制浓度下，两种物质均未使有断裂的细胞或每个细胞的断裂数增加，尽管4CMB在该剂量下确实诱导了间隙的显著增加。在这个系统中，4CMB和BC不是染色体诱变剂。
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