用4-氯甲基联苯和苄氯处理的人淋巴细胞中的姐妹染色单体交换
Sister-chromatid exchanges in human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride.
作者信息
Kirkland D J, Jenkinson P C, Smith K L
出版信息
Mutat Res. 1982 Jan-Feb;100(1-4):301-4. doi: 10.1016/0165-1218(82)90065-9.
PMID:7057765
Abstract
At non-inhibitory concentrations, 4CMB and BC both induced small, but dose-related increases in SCE. The dose-response curves gave a highly significant correlation for 4CMB (r = 0.996, P less than 0.001) and a significant correlation for BC (r = 0.757, P less than 0.05) which reflects the relative activities of these substances in bacterial mutation tests.
摘要
在非抑制浓度下，4 - 氯 - 3,5 - 二甲基苯胺（4CMB）和苄基氯（BC）均诱导姐妹染色单体交换（SCE）出现小幅度但与剂量相关的增加。剂量 - 反应曲线显示，4CMB具有高度显著的相关性（r = 0.996，P < 0.001），BC具有显著相关性（r = 0.757，P < 0.05），这反映了这些物质在细菌突变试验中的相对活性。
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