4CMB对小鼠生殖细胞的影响。
The effect of 4CMB on germ cells of the mouse.
作者信息
Brook J D
出版信息
Mutat Res. 1982 Jan-Feb;100(1-4):305-8. doi: 10.1016/0165-1218(82)90066-0.
PMID:7057766
Abstract
The effect of 4CMB on meiosis in the mouse was studied using both male and female test systems. Females were superovulated and treated with 4CMB at metaphase I and oocytes sampled at metaphase II. Similarly with males, chromosome analysis was made at metaphase II for spermatocytes treated at metaphase I. No increase in the frequency of structural of numerical chromosome abnormalities was noted for treated mice as compared to controls.
摘要
使用雄性和雌性测试系统研究了4CMB对小鼠减数分裂的影响。对雌性小鼠进行超排卵处理，并在减数分裂中期I用4CMB处理，然后在减数分裂中期II采集卵母细胞。雄性小鼠的处理方式类似，在减数分裂中期I用4CMB处理精母细胞，并在减数分裂中期II进行染色体分析。与对照组相比，未观察到处理组小鼠染色体结构或数目异常频率增加。
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