展青霉素是另一种具有染色体断裂作用的霉菌毒素，在体外对中国仓鼠V79-E细胞进行的姐妹染色单体交换试验中呈阴性。

Patulin, a further clastogenic mycotoxin, is negative in the SCE assay in Chinese hamster V79-E cells in vitro.

作者信息

Thust R, Kneist S, Mendel J

出版信息

Mutat Res. 1982 Jan;103(1):91-7. doi: 10.1016/0165-7992(82)90093-8.

Abstract

Patulin is a potent inducer of chromatid-type aberrations in Chinese hamster V79-E cells, but loses its activity when 9000 g supernatant of rat-liver homogenate is added. The narrow dose range of patulin clastogenicity shows a quantitative relationship between absolute amount of mycotoxin applied and the number of indicator cells treated. Within a dose range permitting survival of V79-E, patulin does not induce an increase of the SCE rate. It is suggested that patulin clastogenicity is caused by interaction with chromosomal proteins and that DNA is not the virtual target of this mycotoxin.

摘要

展青霉素是中国仓鼠V79 - E细胞中染色单体型畸变的有效诱导剂，但当添加大鼠肝脏匀浆的9000g上清液时，它会失去活性。展青霉素致染色体断裂活性的狭窄剂量范围表明，所施加的霉菌毒素绝对量与所处理的指示细胞数量之间存在定量关系。在允许V79 - E细胞存活的剂量范围内，展青霉素不会诱导姐妹染色单体交换率增加。有人认为，展青霉素的致染色体断裂活性是由与染色体蛋白质的相互作用引起的，并且DNA不是这种霉菌毒素的实际靶标。