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Sister-chromatid exchange and chromosomal aberration induction in cultured Chinese hamster cells by the monomethylbenz[a]anthracenes.

作者信息

Connell J R

出版信息

Mutat Res. 1982 Sep;102(2):173-82. doi: 10.1016/0165-1218(82)90117-3.

DOI:10.1016/0165-1218(82)90117-3
PMID:7144778
Abstract

The ability of the 12 monomethylbenz[a]anthracene isomers, following their metabolism by using the cell-mediated activation system, to induce 8-azaguanine-resistant mutants, sister-chromatid exchanges (SCEs) and chromosomal aberrations has been measured. Both the mutagenic potency and the ability of the monomethylbenz[a]anthracenes to induce SCEs correlated with their carcinogenic activity. None of the monomethylbenz[a]anthracenes were particularly clastogenic.

摘要

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