Hollingworth P, Melsom R D, Scott J T
Rheumatol Rehabil. 1982 Feb;21(1):9-14. doi: 10.1093/rheumatology/21.1.9.
A new and highly reproducible method for measuring radiographic joint space in the rheumatoid knee is described. The joint space was measured in radiographs of the knees of 120 patients with rheumatoid arthritis and correlated by computer analysis with age, sex, duration of disease, erosions, degenerative change, therapy and Quetelet's index (an index of obesity). Narrowing of both compartments of the knee correlated significantly with the duration of disease. Narrowing of the lateral, but not medial, compartment showed some degree of correlation with obesity as measured by Quetelet's index, but this did not achieve significance. The presence of erosions was associated with marked narrowing of joint space which frequently occurred early in the course of the disease; three-quarters of the patients showing even moderate erosions had at least one knee compartment narrowed to 2 mm or less and in half of these the changes had occurred in less than 10 years. Joint space narrowing also correlated strongly with degenerative change which was, however, remarkable for its infrequency.
本文描述了一种用于测量类风湿性膝关节X线关节间隙的全新且高度可重复的方法。对120例类风湿性关节炎患者膝关节的X线片进行关节间隙测量，并通过计算机分析将其与年龄、性别、病程、糜烂、退行性改变、治疗情况以及奎特利指数（一种肥胖指数）进行关联。膝关节两个腔室的狭窄与病程显著相关。外侧腔室（而非内侧腔室）的狭窄与通过奎特利指数衡量的肥胖存在一定程度的相关性，但未达到显著水平。糜烂的存在与关节间隙明显变窄相关，这种情况在疾病早期经常出现；四分之三表现出中度糜烂的患者至少有一个膝关节腔室狭窄至2毫米或更小，其中一半患者的这些变化发生在不到10年的时间内。关节间隙变窄也与退行性改变密切相关，然而，退行性改变的发生率较低，这一点很显著。
