正常人气道中的β-肾上腺素能激动剂抵抗
beta-adrenergic agonist resistance in normal human airways.
作者信息
Holgate S T, Baldwin C J, Tattersfield A E
出版信息
Lancet. 1977 Aug 20;2(8034):375-7. doi: 10.1016/s0140-6736(77)90304-x.
The response to a beta2-agonist (salbutamol) was assessed by measuring specific airways conductance (sGaw) in healthy volunteers following increasing doses of inhaled or intravenous salbutamol. Regular inhaled salbutamol in doses exceeding 200 microgram four times a day produced a progressive loss of airways responsiveness to both inhaled and intravenous salbutamol (beta-agonist resistance). In salbutamol-resistant subjects full bronchodilator sensitivity was restored 3-5 h after intravenous hydrocortisone.
通过测量健康志愿者吸入或静脉注射不同剂量沙丁胺醇后特定气道传导率（sGaw），评估其对β2受体激动剂（沙丁胺醇）的反应。每天4次规律吸入超过200微克剂量的沙丁胺醇会导致气道对吸入和静脉注射沙丁胺醇的反应性逐渐丧失（β受体激动剂抵抗）。在沙丁胺醇抵抗的受试者中，静脉注射氢化可的松3 - 5小时后，完全支气管扩张剂敏感性得以恢复。
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