McCarter R J, Masoro E J, Yu B P
Am J Physiol. 1982 Jan;242(1):R89-93. doi: 10.1152/ajpregu.1982.242.1.R89.
Age changes in oxygen consumption and the structural composition of the lateral omohyoideus muscle were studied in adult male rats. The rate were either fed ad libitum (group A) or 60% of the ad libitum intake (group R). An age-related loss in muscle mass did not occur even at advanced ages in group A or group R rats. Muscle fiber diameter decreased with age in both groups but a concomitant increase in the number of fibers prevented a change in muscle mass. The muscles of group R rats contained the same number of fibers as those of group A rats at all ages. The muscles of group A rats showed a progressive loss in rate of resting oxygen consumption until 18 mo of age. A similar but less marked loss in oxygen consumption occurred in the muscles of group R rats. These results provide further evidence that life-prolonging food restriction modulates physiological changes associated with the aging process.
在成年雄性大鼠中研究了肩胛舌骨肌外侧部耗氧量和结构组成的年龄变化。大鼠分为两组，一组自由进食（A组），另一组进食量为自由进食量的60%（R组）。即使在老龄时，A组或R组大鼠的肌肉质量也没有出现与年龄相关的下降。两组中肌纤维直径均随年龄减小，但纤维数量同时增加，从而防止了肌肉质量的改变。R组大鼠肌肉在所有年龄阶段的纤维数量与A组相同。A组大鼠肌肉的静息耗氧率在18月龄前逐渐下降。R组大鼠肌肉也出现了类似但不太明显的耗氧量下降。这些结果进一步证明，延长寿命的食物限制可调节与衰老过程相关的生理变化。
