Upadhyay S, Zamboni L
Anat Rec. 1982 Jan;202(1):105-111. doi: 10.1002/ar.1092020112.
The interrelationship between mesonephros, adrenal cortex, and gonads was studied in 28- and 31-day old sheep fetuses by means of light microscopy on plastic sections. At these stages, the adrenal cortex is just beginning to develop and mesonephros is undergoing involution; its regression is accompanied by mobilization of cells from the glomerulus of a peculiar nephron situated in the proximal third of the organ, and referred to as "giant" because of its large size. The mobilized cells egress from this glomerulus organized in trabeculae, some of which reach the cranial extremity of the adrenal cortex while others coalesce into a prominent cellular formation which extends uninterrupted toward and into the developing gonads. In previous studies we have shown that the mesonephric cells which colonize the gonads differentiate into sustentacular and interstitial steroidogenic cells; the presence of an analogous cellular migration from the mesonephros to the adrenal cortex now suggests that also the adrenal cortical cells may be of mesonephric origin.
通过对塑料切片进行光学显微镜观察，研究了28日龄和31日龄绵羊胎儿中肾、肾上腺皮质和性腺之间的相互关系。在这些阶段，肾上腺皮质刚刚开始发育，中肾正在退化；中肾的退化伴随着一种特殊肾单位肾小球细胞的动员，这种肾单位位于器官近端三分之一处，因其体积大而被称为“巨型”。动员的细胞从这个肾小球以小梁形式排出，其中一些到达肾上腺皮质的头端，而另一些则聚合成一个突出的细胞团，该细胞团不间断地向发育中的性腺延伸并进入性腺。在先前的研究中，我们已经表明，定殖于性腺的中肾细胞分化为支持细胞和间质类固醇生成细胞；现在从中肾到肾上腺皮质存在类似的细胞迁移，这表明肾上腺皮质细胞也可能起源于中肾。
