Winnan G R, Meyer C T, McCallum R W
Ann Intern Med. 1982 Mar;96(3):320-2. doi: 10.7326/0003-4819-96-3-320.
We evaluated the esophageal acid infusion test (Bernstein test) in respect to the following questions: Does chest pain predictably disappear after cessation of acid infusion, and what is the relation between esophageal intraluminal pH and the degree of chest pain relief? Forty patients with subjective and objective evidence of gastroesophageal acid reflux, in whom esophageal acid infusion had reproduced substernal burning in a mean time of 3.1 minutes +/- 0.8 SE, graded pain relief after stopping acid infusion when saline was being infused. Complete pain relief occurred in 47.5% of patients over a 20-minute period. In six patients, esophageal pH was monitored for 30 minutes after administration of saline, antacid, placebo-antacid, and no treatment for a positive acid infusion test. Esophageal pH returned to normal (greater than 4.0) at the same rate (from 5.0 to 8.3 minutes) among patients in the four treatment groups, whereas chest pain continued and esophageal pH did not correlate with pain relief. The grading of pain relief was similar among the treatment groups, except at the 5-minute period when antacids resulted in significantly better relief than no treatment.
我们针对以下问题评估了食管酸灌注试验（伯恩斯坦试验）：停止酸灌注后胸痛是否可预测地消失，以及食管腔内pH值与胸痛缓解程度之间有何关系？40例有胃食管酸反流主观和客观证据的患者，食管酸灌注平均在3.1分钟±0.8标准误时再现胸骨后烧灼感，在输注生理盐水时停止酸灌注后对疼痛缓解程度进行分级。在20分钟内，47.5%的患者疼痛完全缓解。对6例酸灌注试验阳性的患者，在给予生理盐水、抗酸剂、安慰剂 - 抗酸剂以及不治疗后，监测食管pH值30分钟。四个治疗组患者的食管pH值以相同速率（从5.0至8.3分钟）恢复正常（大于4.0），而胸痛持续存在，且食管pH值与疼痛缓解无关。各治疗组疼痛缓解分级相似，除了在5分钟时抗酸剂导致的缓解明显优于不治疗。
