Beckman D L, Iams S G
Undersea Biomed Res. 1978 Sep;5(3):253-7.
A variety of autonomic blocking agents, general anesthetics, and anticonvulsants have been shown to offer protection from seizures caused by hyperbaric oxygen. Amino-oxyacetic acid (AOAA) has been shown to offer rats only minimal protection from such seizures. This study investigated whether AOAA protected cats and mice from hyperbaric-oxygen-induced seizures. Cats and mice were exposed to 100% oxygen at 5 ATA until seizures occurred or for a period of up to 60 min. Approximately half of the animals were pretreated with AOAA either 30 or 240 min before oxygen exposure. Results showed that the interval between exposure and grand mal seizures increased significantly in cats pretreated 30 or 240 min before exposure with 17 to 25 mg/kg AOAA; the number of cats remaining seizure-free for 60 min also increased markedly. However, mice received little protection even at doses up to 40 mg/kg. At higher doses the AOAA itself caused seizures even in the absence of hyperbaric oxygen.
已证实多种自主神经阻滞剂、全身麻醉剂和抗惊厥药可预防高压氧引起的癫痫发作。已证实氨基氧乙酸（AOAA）仅能为大鼠提供对这类癫痫发作的最小保护。本研究调查了AOAA是否能保护猫和小鼠免受高压氧诱发的癫痫发作。将猫和小鼠置于5个绝对大气压的100%氧气环境中，直至癫痫发作或长达60分钟。大约一半的动物在氧气暴露前30或240分钟用AOAA进行预处理。结果显示，在暴露前30或240分钟用17至25毫克/千克AOAA预处理的猫，暴露与全身强直阵挛性发作之间的间隔显著增加；癫痫发作持续60分钟仍未发作的猫的数量也显著增加。然而，即使给予高达40毫克/千克的剂量，小鼠也几乎没有得到保护。在更高剂量下，即使没有高压氧，AOAA本身也会引发癫痫发作。
