Jamieson D, Carmody J
Aviat Space Environ Med. 1987 Jun;58(6):541-4.
In mice, oxygen at hyperbaric pressures (515 kPa; 5 ATA) induces convulsions and lung damage (edema and hemorrhage). Morphine treatment (15 mg X kg-1, i.p.) significantly protects against the development of this pathology. The protection is abolished by naloxone (1 mg X kg-1, i.p.). Electric footshock, which induces diverse opioid effects, affords no protection against hyperbaric oxygen damage. Possible mechanisms of the morphine action are discussed.
在小鼠中，高压氧（515 kPa；5个绝对大气压）会引发惊厥和肺损伤（水肿和出血）。吗啡治疗（15毫克/千克，腹腔注射）可显著预防这种病理状况的发展。纳洛酮（1毫克/千克，腹腔注射）可消除这种保护作用。能引发多种阿片样物质作用的电休克对高压氧损伤没有保护作用。文中讨论了吗啡作用的可能机制。
