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山羊减压病:48小时时脑和脊髓损伤的性质

Decompression sickness in the goat: nature of brain and spinal cord lesions at 48 hours.

作者信息

Palmer A C, Blakemore W F, Payne J E, Sillence A

出版信息

Undersea Biomed Res. 1978 Sep;5(3):275-86.

PMID:705944
Abstract

An investigation was undertaken to determine whether permanent damage to the central nervous system (CNS) is associated with transient decompression sickness in the goat. Twelve goats were compressed in air at 100 fsw for one hour. After decompression over a period of 2.5 min, seven animals showed signs of decompression sickness and four of these were treated by recompression in oxygen. Residual clinical signs after 12 h were present in one animal only. The seven affected goats were killed 48 h after decompression. Lesions in the CNS (other than hemorrhage) were confined to the spinal cord of three animals that had shown paralysis, and consisted of infarction of white matter with occasional microthrombi and perivascular proteinaceous edema of the gray matter. In all seven animals, there was hemorrhage in the spinal cord and in four, hemorrhage in the brain. Infarction of the spinal cord was not present in the four animals that had shown only slight clinical signs (limping); one of these goats had been treated by recompression in oxygen.

摘要

开展了一项调查,以确定山羊的中枢神经系统(CNS)永久性损伤是否与短暂性减压病有关。12只山羊在100英尺海水深度的空气中压缩1小时。在2.5分钟的减压过程后,7只动物出现减压病症状,其中4只通过在氧气中再加压进行治疗。仅1只动物在12小时后仍有残留临床症状。7只受影响的山羊在减压后48小时被处死。中枢神经系统的病变(除出血外)局限于3只出现麻痹的动物的脊髓,包括白质梗死,偶尔有微血栓形成,以及灰质的血管周围蛋白质性水肿。在所有7只动物中,脊髓均有出血,4只动物脑部有出血。4只仅表现出轻微临床症状(跛行)的动物脊髓未出现梗死;其中1只山羊通过在氧气中再加压进行了治疗。

相似文献

1
Decompression sickness in the goat: nature of brain and spinal cord lesions at 48 hours.山羊减压病:48小时时脑和脊髓损伤的性质
Undersea Biomed Res. 1978 Sep;5(3):275-86.
2
Acute neurologic decompression illness in pigs: lesions of the spinal cord and brain.猪的急性神经减压病:脊髓和脑部病变
Lab Anim Sci. 1997 Feb;47(1):50-7.
3
Nature and incidence of bubbles in the spinal cord of decompressed goats.减压山羊脊髓中气泡的性质与发生率
Undersea Hyperb Med. 1997 Sep;24(3):193-200.
4
Myelopathy associated with decompression sickness: a report of six cases.与减压病相关的脊髓病:6例报告
Clin Exp Neurol. 1983;19:54-9.
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Magnetic resonance imaging and neuropathology findings in the goat nervous system following hyperbaric exposures.高压暴露后山羊神经系统的磁共振成像和神经病理学发现。
Eur Neurol. 2004;52(1):18-28. doi: 10.1159/000079254. Epub 2004 Jun 22.
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Role of extravascular gas bubbles in spinal cord injury induced by decompression sickness in the rat.血管外气泡在大鼠减压病所致脊髓损伤中的作用
Exp Mol Pathol. 1994 Aug;61(1):16-23. doi: 10.1006/exmp.1994.1022.
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Protective effect of oxygen and heliox breathing during development of spinal decompression sickness.氧气和氦氧混合气吸入对脊髓减压病发展过程的保护作用
Undersea Hyperb Med. 1994 Jun;21(2):115-28.
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Venous infarction of the spinal cord in decompression sickness.减压病所致脊髓静脉梗死
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引用本文的文献

1
Dysbarism: the medical problems from high and low atmospheric pressure.气压病:由高低气压引起的医学问题。
J R Coll Physicians Lond. 1993 Oct;27(4):367-74.
2
Bubbles and hematologic alterations in intracranial veins during experimental decompression sickness.实验性减压病期间颅内静脉中的气泡与血液学改变
Acta Neuropathol. 1983;59(2):139-44. doi: 10.1007/BF00691600.
3
Spinal cord degeneration in a case of "recovered" spinal decompression sickness.一例“已康复”的脊髓减压病患者的脊髓退变
Br Med J (Clin Res Ed). 1981 Oct 3;283(6296):888. doi: 10.1136/bmj.283.6296.888.