Sharpe R P, Broome J R
Naval Medical Research Institute, Bethesda, Maryland 20889-5607, USA.
Undersea Hyperb Med. 1997 Winter;24(4):323-8.
Spinal cord lipid content was analyzed in 50 pigs that had experienced a simulated dive known to produce 20-80% incidence of neurologic decompression sickness (DCS). Using air and heliox as breathing mixtures, these animals underwent chamber dives ranging from 200-250 feet of seawater (fsw). These dives were designed to generate spinal cord DCS, which was detected by observing the animals for gross neurologic deficits. Using a standardized method, cylindrical samples of cord were cut from different spinal levels and analyzed for total lipid (TL) content, which produced two cervical, three thoracic, and two lumbar samples. All areas with gross hemorrhage were also sampled. The range of TL (mean) in milligrams per gram from the cervical, thoracic, and lumbar regions were 118-679 (319), 140-635 (366), and 109-658 (307), respectively. Although this implies that TL varies markedly between cords, values within each cord were fairly consistent (+/- 20% from cord mean). The difference in TL values between cord regions with and without hemorrhage was not significant (P > 0.1). This reveals that increased spinal cord TL levels, together with their presumed dissolved inert gas, do not play a major role in the location or incidence of spinal cord hemorrhages in pigs with clinical signs of spinal cord DCS.
对50头猪的脊髓脂质含量进行了分析，这些猪经历了模拟潜水，已知这种潜水会导致20%-80%的神经减压病（DCS）发病率。这些动物使用空气和氦氧混合气作为呼吸气体，在相当于200-250英尺海水深度（fsw）的高压舱中潜水。这些潜水旨在引发脊髓DCS，通过观察动物的明显神经功能缺损来检测。采用标准化方法，从不同脊髓节段切取圆柱形脊髓样本，分析其总脂质（TL）含量，共获得两个颈部、三个胸部和两个腰部样本。所有出现明显出血的区域也进行了取样。颈部、胸部和腰部区域每克TL（毫克）的范围分别为118-679（319）、140-635（366）和109-658（307）。虽然这意味着不同脊髓之间的TL差异显著，但每根脊髓内的值相当一致（与脊髓平均值相差±20%）。有出血和无出血的脊髓区域之间TL值的差异不显著（P>0.1）。这表明，脊髓TL水平升高及其假定的溶解惰性气体，在出现脊髓DCS临床症状的猪的脊髓出血位置或发生率方面不起主要作用。
