使用颊部分隔作为模型来研究氢氧化铝凝胶对普萘洛尔吸收的影响。
The use of buccal partitioning as a model to examine the effects of aluminium hydroxide gel on the absorption of propranolol.
作者信息
McElnay J C, Temple D J
出版信息
Br J Clin Pharmacol. 1982 Mar;13(3):399-403. doi: 10.1111/j.1365-2125.1982.tb01392.x.
Abstract
1 A buccal partitioning model showed no absorption interaction between propranolol and aluminium hydroxide gel in three volunteer subjects. 2 The previously reported in vivo interaction is therefore not due to propranolol adsorption to, or complexation with the antacid but is more probably due to a decreased gastric emptying rate caused by the antacid. 2 Buccal partitioning has proved useful in the examination of the mechanism of the propranolol/aluminium hydroxide absorption interaction and may also be a suitable in vivo bioavailability screening model for other drugs which can be partitioned in the buccal membranes.
摘要
- 一个口腔分隔模型显示，在三名志愿者受试者中，普萘洛尔与氢氧化铝凝胶之间不存在吸收相互作用。2. 因此，先前报道的体内相互作用并非由于普萘洛尔吸附于抗酸剂或与抗酸剂络合，而更可能是由于抗酸剂导致胃排空速率降低。2. 口腔分隔已被证明在研究普萘洛尔/氢氧化铝吸收相互作用机制方面有用，并且可能也是其他可在口腔黏膜中分隔的药物的合适体内生物利用度筛选模型。
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The use of buccal partitioning as a model to examine the effects of aluminium hydroxide gel on the absorption of propranolol.使用颊部分隔作为模型来研究氢氧化铝凝胶对普萘洛尔吸收的影响。
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Br J Clin Pharmacol. 1980 Jul;10(1):61-5. doi: 10.1111/j.1365-2125.1980.tb00502.x.
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