The use of buccal partitioning as a model to examine the effects of aluminium hydroxide gel on the absorption of propranolol.
作者信息
McElnay J C, Temple D J
出版信息
Br J Clin Pharmacol. 1982 Mar;13(3):399-403. doi: 10.1111/j.1365-2125.1982.tb01392.x.
Abstract
1 A buccal partitioning model showed no absorption interaction between propranolol and aluminium hydroxide gel in three volunteer subjects. 2 The previously reported in vivo interaction is therefore not due to propranolol adsorption to, or complexation with the antacid but is more probably due to a decreased gastric emptying rate caused by the antacid. 2 Buccal partitioning has proved useful in the examination of the mechanism of the propranolol/aluminium hydroxide absorption interaction and may also be a suitable in vivo bioavailability screening model for other drugs which can be partitioned in the buccal membranes.
摘要
相似文献
1
The use of buccal partitioning as a model to examine the effects of aluminium hydroxide gel on the absorption of propranolol.
Br J Clin Pharmacol. 1982 Mar;13(3):399-403. doi: 10.1111/j.1365-2125.1982.tb01392.x.
2
Drug recovery following buccal absorption of propranolol.
Br J Clin Pharmacol. 1980 Jul;10(1):61-5. doi: 10.1111/j.1365-2125.1980.tb00502.x.
3
The use of buccal partitioning as a model of drug absorption interactions.
J Clin Hosp Pharm. 1983 Jun;8(2):137-42. doi: 10.1111/j.1365-2710.1983.tb01043.x.
4
Examination of the chloroquine-kaolin drug absorption interaction using the buccal partitioning model.
J Clin Hosp Pharm. 1982 Dec;7(4):269-73. doi: 10.1111/j.1365-2710.1982.tb01032.x.
5
[Antacid action of the aluminum cation: comparison of the in vitro effect of hydroxide and phosphate in open and closed systems].
Gastroenterol Clin Biol. 1987 Nov;11(11):758-63.
6
A membrane model of the human oral mucosa as derived from buccal absorption performance and physicochemical properties of the beta-blocking drugs atenolol and propranolol.
J Pharm Pharmacol. 1978 Mar;30(3):137-47. doi: 10.1111/j.2042-7158.1978.tb13185.x.
7
Lack of influence of aluminum hydroxide on the bioavailability and beta-adrenoceptor blocking activity of propranolol.
Int J Clin Pharmacol Ther Toxicol. 1985 May;23(5):244-6.
8
The different effects of sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin in man.
Postgrad Med J. 1977 Mar;53(617):126-9. doi: 10.1136/pgmj.53.617.126.
9
The effect of activated dimethicone, other antacid constituents, and kaolin on the absorption of propranolol.
Experientia. 1982 May 15;38(5):605-7. doi: 10.1007/BF02327075.
引用本文的文献
1
The effect of pH on the buccal and sublingual absorption of captopril.
Eur J Clin Pharmacol. 1995;48(5):373-9. doi: 10.1007/BF00194953.
2
Drug interactions with antacids. Mechanisms and clinical significance.
Drug Saf. 1994 Dec;11(6):395-407. doi: 10.2165/00002018-199411060-00002.
本文引用的文献
1
Drug recovery following buccal absorption of propranolol.
Br J Clin Pharmacol. 1980 Jul;10(1):61-5. doi: 10.1111/j.1365-2125.1980.tb00502.x.
2
Interference of iron with the absorption of tetracyclines in man.
Br Med J. 1970 Nov 28;4(5734):532-4. doi: 10.1136/bmj.4.5734.532.
3
Kinetics of buccal absorption of amphetamines.
J Pharm Pharmacol. 1968 Feb;20(2):92-7. doi: 10.1111/j.2042-7158.1968.tb09695.x.
4
Effects of antacids on gastric emptying.
Gastroenterology. 1976 Aug;71(2):268-73.
5
The buccal absorption characteristics of fomocaine.
Arch Pharm (Weinheim). 1978 Jun;311(6):485-91. doi: 10.1002/ardp.19783110606.
6
Interaction of digoxin with activated dimethicone and other antacid constituents.
Experientia. 1979 Jan 15;35(1):94. doi: 10.1007/BF01917899.
7
A model for steroid transport across biological membranes.
J Pharm Pharmacol. 1975 Apr;27(4):226-34. doi: 10.1111/j.2042-7158.1975.tb10691.x.
8
Effects of antacids on gastrointestinal absorption of drugs.
Prim Care. 1976 Sep;3(3):537-50.
9
An in vitro model of drug-metal ion interactions in the gut [proceedings].
J Pharm Pharmacol. 1976 Dec;28 Suppl:33P.
Zotero 插件