碳酸氢钠和氢氧化铝对人体吲哚美辛吸收的不同影响。
The different effects of sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin in man.
作者信息
Garnham J C, Kaspi T, Kaye C M, Oh V M
出版信息
Postgrad Med J. 1977 Mar;53(617):126-9. doi: 10.1136/pgmj.53.617.126.
Abstract
The influence of oral sodium bicarbonate and aluminium hydroxide on the absorption of indomethacin has been studied in normal volunteers. While sodium bicarbonate appeared to increase indomethacin absorption, aluminium hydroxide markedly reduced both the rate and extent of absorption. The buccal absorption of indomethacin over the pH range 5-9 was also studied in normal volunteers, and showed that the percentage absorption increased markedly as the pH was reduced. The clinical importance both of pH-partition and of adsorption are discussed in the context of antacid interactions. It is concluded that caution must be exercised when prescribing an antacid with other orally-administered drugs.
摘要
在正常志愿者中研究了口服碳酸氢钠和氢氧化铝对吲哚美辛吸收的影响。虽然碳酸氢钠似乎会增加吲哚美辛的吸收，但氢氧化铝显著降低了吸收速率和吸收程度。还在正常志愿者中研究了pH值范围为5 - 9时吲哚美辛的颊部吸收情况，结果表明随着pH值降低，吸收百分比显著增加。在抗酸剂相互作用的背景下讨论了pH分配和吸附的临床重要性。得出的结论是，在开具抗酸剂与其他口服药物联用时必须谨慎。
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