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铁对人体吸收四环素的干扰。

Interference of iron with the absorption of tetracyclines in man.

作者信息

Neuvonen P J, Gothoni G, Hackman R, Björksten K

出版信息

Br Med J. 1970 Nov 28;4(5734):532-4. doi: 10.1136/bmj.4.5734.532.

DOI:10.1136/bmj.4.5734.532
PMID:5483323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1820021/
Abstract

Ferrous sulphate administered together with tetracycline and three of its derivatives-oxytetracycline, methacycline, and doxycycline-was found seriously to impair the absorption of these antibiotics. Thus even small doses of iron taken simultaneously should be avoided during tetracycline treatment.

摘要

硫酸亚铁与四环素及其三种衍生物——土霉素、甲烯土霉素和强力霉素——一起服用时,会严重损害这些抗生素的吸收。因此,在四环素治疗期间,即使同时服用小剂量的铁也应避免。

相似文献

1
Interference of iron with the absorption of tetracyclines in man.铁对人体吸收四环素的干扰。
Br Med J. 1970 Nov 28;4(5734):532-4. doi: 10.1136/bmj.4.5734.532.
2
Influence of repetitive dosing of tetracyclines on biologic half-life in serum.
Clin Pharmacol Ther. 1969 Sep-Oct;10(5):690-701. doi: 10.1002/cpt1969105690.
3
The oral absorption of doxycycline by man.
Int Z Klin Pharmakol Ther Toxikol. 1969 Jan;2(1):52-5.
4
[Tetracycline kinetics in man. Digestive absorption and serum concentration].[人体中的四环素动力学。消化吸收与血清浓度]
Schweiz Med Wochenschr. 1971 May 1;101(17):593-8.
5
[Influence of iron preparations on the absorption of tetracyclines].
Tidsskr Nor Laegeforen. 1971 Oct 10;91(28):2028.
6
[Effect of renal insufficiency on the action of doxycycline].[肾功能不全对多西环素作用的影响]
J Urol Nephrol (Paris). 1968 Dec;74(12):1038-47.
7
[A comparative study of the circulation of oxytetracycline and its derivatives--methacycline and doxycycline--in the bodies of animals].
Antibiotiki. 1973 Nov;18(11):1041-6.
8
Treatment of gonorrhea. Tetracyclines.淋病的治疗。四环素类药物。
J Reprod Med. 1973 Oct;11(4):179-81.
9
[Absorption of tetracyclines].[四环素的吸收]
Tidsskr Nor Laegeforen. 1973 May 10;93(13):945-6.
10
Metal ion-tetracycline interactions in biological fluids. Part 3. Formation of mixed-metal ternary complexes of tetracycline, oxytetracycline, doxycycline and minocycline with calcium and magnesium, and their involvement in the bioavailability of these antibiotics in blood plasma.生物流体中的金属离子-四环素相互作用。第3部分。四环素、土霉素、强力霉素和米诺环素与钙和镁的混合金属三元络合物的形成,以及它们对这些抗生素在血浆中生物利用度的影响。
Agents Actions. 1984 Jun;14(5-6):743-50. doi: 10.1007/BF01978919.

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本文引用的文献

1
The effects of various substances on the absorption of tetracycline in rats.
Antibiotic Med Clin Ther (New York). 1957 Oct;4(10):627-41.
2
Avidity of the tetracyclines for the cations of metals.四环素对金属阳离子的亲合力。
Nature. 1956 Mar 3;177(4505):433-4. doi: 10.1038/177433a0.
3
Inhibition of intestinal iron transport induced by tetracycline.四环素对肠道铁转运的抑制作用。
Gastroenterology. 1967 Oct;53(4):590-9.
4
Comparison of in vitro activity and clinical pharmacology of doxycycline with other tetracyclines.多西环素与其他四环素类药物的体外活性及临床药理学比较。
Antimicrob Agents Chemother (Bethesda). 1966;6:134-41.