老年人苯妥英的血浆蛋白结合：体内研究
Plasma protein binding of phenytoin in the aged: in vivo studies.
作者信息
Patterson M, Heazelwood R, Smithurst B, Eadie M J
出版信息
Br J Clin Pharmacol. 1982 Mar;13(3):423-5. doi: 10.1111/j.1365-2125.1982.tb01396.x.
Abstract
1 The relation between plasma water phenytoin content and whole plasma phenytoin content in vivo was studied in 22 elderly patients (age range 62 to 87 years) and in 22 young patients (age range 18 to 33 years), all of whom were taking the drug for epilepsy. 2 The percentage of the drug existing unbound in plasma was slightly, but statistically significantly, higher in the elderly (12.8 +/- 1.8%) than in the young (11.1 +/- 2.5%). Reduced plasma albumin levels in the elderly (33.0 +/- 2.0 gl-1) as compared with the young (45.3 +/- 3.5 gl-1) probably contributed to the reduced protein binding in the older subjects.
摘要
- 对22名老年患者（年龄范围62至87岁）和22名年轻患者（年龄范围18至33岁）进行了研究，这些患者均因癫痫正在服用苯妥英药物，研究了体内血浆水苯妥英含量与全血浆苯妥英含量之间的关系。2. 药物在血浆中未结合形式存在的百分比在老年人中略高，但具有统计学意义，老年人为（12.8±1.8%），年轻人为（11.1±2.5%）。与年轻人（45.3±3.5 g/l）相比，老年人血浆白蛋白水平降低（33.0±2.0 g/l），这可能导致老年受试者蛋白质结合减少。
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本文引用的文献
1
Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography.气液色谱法快速测定血浆中的苯妥英
Anal Chem. 1970 Mar;42(3):421-2. doi: 10.1021/ac60285a024.
2
Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal and hepatic disease.苯妥英钠的血浆蛋白结合。性激素、肾脏和肝脏疾病的影响。
Clin Pharmacol Ther. 1974 Mar;15(3):276-82. doi: 10.1002/cpt1974153276.
3
Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution.人体内苯妥英钠的血浆蛋白结合。与其他药物的相互作用以及温度和血浆稀释的影响。
Clin Pharmacol Ther. 1970 Nov-Dec;11(6):846-55. doi: 10.1002/cpt1970116846.
4
Protein binding of diphenylhydantoin and desmethylimipramine in plasma from patients with poor renal function.肾功能不全患者血浆中苯妥英钠和去甲丙咪嗪的蛋白结合情况。
N Engl J Med. 1971 Jul 29;285(5):264-7. doi: 10.1056/NEJM197107292850506.
5
The effect of certain drugs on the plasma protein binding of phenytoin.某些药物对苯妥英血浆蛋白结合的影响。
Aust N Z J Med. 1973 Aug;3(4):377-81. doi: 10.1111/j.1445-5994.1973.tb03109.x.
6
Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.药物代谢随年龄增长的变化：2. 苯妥英钠清除率与蛋白结合率
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7
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8
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9
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10
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