药物代谢随年龄增长的变化：2. 苯妥英钠清除率与蛋白结合率
Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.
作者信息
Hayes M J, Langman M J, Short A H
出版信息
Br J Clin Pharmacol. 1975 Feb;2(1):73-9. doi: 10.1111/j.1365-2125.1975.tb00475.x.
Abstract
1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were found to be reduced in the elderly.
摘要
- 苯妥英清除率的比较显示，65岁以上人群与45岁以下人群相比有显著增加。2. 如果口服或静脉注射苯妥英，这种差异很明显。3. 苯妥英清除率与苯妥英结合及血浆白蛋白呈负相关，二者在老年人中均降低。
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