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药物代谢随年龄增长的变化：2. 苯妥英钠清除率与蛋白结合率

Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.

作者信息

Hayes M J, Langman M J, Short A H

出版信息

Br J Clin Pharmacol. 1975 Feb;2(1):73-9. doi: 10.1111/j.1365-2125.1975.tb00475.x.

DOI:10.1111/j.1365-2125.1975.tb00475.x
PMID:1234490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1402501/
Abstract

1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were found to be reduced in the elderly.

摘要
  1. 苯妥英清除率的比较显示，65岁以上人群与45岁以下人群相比有显著增加。2. 如果口服或静脉注射苯妥英，这种差异很明显。3. 苯妥英清除率与苯妥英结合及血浆白蛋白呈负相关，二者在老年人中均降低。

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Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.药物代谢随年龄增长的变化：2. 苯妥英钠清除率与蛋白结合率
Br J Clin Pharmacol. 1975 Feb;2(1):73-9. doi: 10.1111/j.1365-2125.1975.tb00475.x.
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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The metabolic fate of diphenylhydantoin in the dog, rat and man.二苯乙内酰脲在犬、大鼠和人体内的代谢转归。
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A graphic method for the determination and presentation of binding parameters in a complex system.一种用于确定和呈现复杂系统中结合参数的图形方法。
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Studies on the coumarin anticoagulant drugs: interaction of human plasma albumin and warfarin sodium.香豆素类抗凝药物的研究：人血浆白蛋白与华法林钠的相互作用
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The determination of human serum albumin by its specific binding of the anionic dye, 2-(4'-hydroxybenzeneazo)-benzoic acid.通过阴离子染料2-（4'-羟基苯偶氮）苯甲酸的特异性结合来测定人血清白蛋白。
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6
Effect of age and sex on human drug metabolism.年龄和性别对人体药物代谢的影响。
Br Med J. 1971 Sep 11;3(5775):607-9. doi: 10.1136/bmj.3.5775.607.
7
Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography.气液色谱法快速测定血浆中的苯妥英
Anal Chem. 1970 Mar;42(3):421-2. doi: 10.1021/ac60285a024.
8
The rate of decline of diphenylhydantoin in human plasma.人体血浆中苯妥英的下降速率。
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):121-34. doi: 10.1002/cpt1970111121.
9
Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution.人体内苯妥英钠的血浆蛋白结合。与其他药物的相互作用以及温度和血浆稀释的影响。
Clin Pharmacol Ther. 1970 Nov-Dec;11(6):846-55. doi: 10.1002/cpt1970116846.
10
Serum protein binding of thyroxine and diphenylhydantoin.
J Clin Endocrinol Metab. 1966 Mar;26(3):305-8. doi: 10.1210/jcem-26-3-305.