Bell J, Gruenthal M, Finger S, Lundberg P, Johnson E
Brain Res. 1982 Feb 25;234(2):409-21. doi: 10.1016/0006-8993(82)90880-0.
Female rats immunized with mouse nerve growth factor develop an antibody (anti-NGF) which reaches offspring through the placenta and via the milk. Pups exposed to maternal anti-NGF have fewer dorsal root and sympathetic neurons. When the offspring are examined on a wide variety of behavioral tests, they exhibit severe deficits in response to stress (ulceration, corticosterone levels), and mild deficits on some sensory and cognitive tasks. Exploratory and motor functions, however, are relatively normal. The pathologic and behavioral profiles of the animals closely mimic the sensory and sympathetic aspects of familial dysautonomia.
用小鼠神经生长因子免疫的雌性大鼠会产生一种抗体（抗神经生长因子），该抗体可通过胎盘和乳汁传递给后代。暴露于母体抗神经生长因子的幼崽背根神经元和交感神经元数量减少。当对后代进行各种行为测试时，它们在应对压力方面（溃疡、皮质酮水平）表现出严重缺陷，在一些感觉和认知任务上表现出轻微缺陷。然而，探索和运动功能相对正常。这些动物的病理和行为特征与家族性自主神经功能障碍的感觉和交感神经方面非常相似。
