Senge T, Schenck B, Tunn U, Hülshoff T, Neumann F
Urol Res. 1978;6(3):167-71. doi: 10.1007/BF00261318.
The capacity of Leydig cells for regeneration was investigated in 12 patients with prostatic carcinoma, who underwent subcapsular orchidectomy, and in rats after testicular necrosis produced by cadmium chloride. In rats, reappearance of Leydig cells originating from the tunica albuginea could be demonstrated by histology. Testosterone concentrations increased parallel to regeneration of Leydig cells, while LH concentrations declined. In contrast to these findings, no rise of testosterone concentrations could be observed in patients up to 8 months after subcapsular orchidectomy. Human Leydig cells seem to have no capacity for regeneration, or endocrine function, despite the fact that some of these cells, which are present morphologically in the tunica albuginea or spermatic cord, remained.
在12例接受包膜下睾丸切除术的前列腺癌患者以及氯化镉致睾丸坏死的大鼠中，研究了睾丸间质细胞的再生能力。在大鼠中，通过组织学可证实起源于白膜的睾丸间质细胞再次出现。睾酮浓度的升高与睾丸间质细胞的再生平行，而促黄体生成素（LH）浓度下降。与这些发现相反，在包膜下睾丸切除术后长达8个月的患者中，未观察到睾酮浓度升高。尽管在白膜或精索中形态学上仍存在一些人类睾丸间质细胞，但人类睾丸间质细胞似乎没有再生能力或内分泌功能。
