Willemse P H, Sleijfer D T, Sluiter W J, Schraffordt Koops H, Doorenbos H
Acta Endocrinol (Copenh). 1983 Apr;102(4):616-24. doi: 10.1530/acta.0.1020616.
In search of an abnormality in Leydig cell function in patients with testicular cancer, serum levels of testosterone, oestradiol, LH and FSH were compared in 3 groups of men. Group I comprised 26 patients studied after recent orchidectomy for a testicular carcinoma, group II 8 patients operated for benign testicular lesions and group III 8 normal controls. In group II normal testosterone values were found as a result of increased LH release. In group I patients, however, testosterone levels often were low, despite elevated LH levels and increased LH capacity. Evidently, in these patients a partial Leydig cell insufficiency may be present, which does not recover within one year of orchidectomy. After removal of one testis for benign disease, normal testosterone levels are maintained by increased LH levels. After orchidectomy for testicular carcinoma a partial Leydig cell insufficiency may be revealed, which seems to have a permanent character. A pre-existent Leydig cell insufficiency of the remaining testis in patients with testicular cancer indicates a bilateral testicular defect.
为了探寻睾丸癌患者睾丸间质细胞功能的异常情况，对三组男性的血清睾酮、雌二醇、促黄体生成素（LH）和促卵泡生成素（FSH）水平进行了比较。第一组包括26例近期因睾丸癌接受睾丸切除术后的患者，第二组包括8例因良性睾丸病变接受手术的患者，第三组为8名正常对照者。在第二组中，由于LH释放增加，睾酮值正常。然而，在第一组患者中，尽管LH水平升高且LH分泌能力增强，但睾酮水平常常较低。显然，这些患者可能存在部分睾丸间质细胞功能不全，且在睾丸切除术后一年内无法恢复。因良性疾病切除一侧睾丸后，LH水平升高可维持正常的睾酮水平。睾丸癌患者接受睾丸切除术后，可能会出现部分睾丸间质细胞功能不全，且似乎具有永久性。睾丸癌患者剩余睾丸预先存在的睾丸间质细胞功能不全表明存在双侧睾丸缺陷。
