单侧颈动脉结扎对脑干苯乙醇胺 N - 甲基转移酶活性的影响。
Effect of unilateral carotid ligation on brainstem PNMT activity.
作者信息
Yamori Y, Horie R, Fujiwara M, Lovenberg W
出版信息
Eur J Pharmacol. 1982 Feb 5;77(4):317-20. doi: 10.1016/0014-2999(82)90135-2.
Phenylethanolamine N-methyltransferase (PNMT) activity in the C1 and C2 regions of the brainstem was assayed in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) with or without unilateral carotid artery ligation. PNMT activity was significantly higher in SHR than in WKY (P less than 0.01). PNMT activity in the C1 and C2 regions on non-ligated side in both WKY and SHR was significantly elevated compared with that on the ligated side. These results indicate that the activity of PNMT in adrenergic neurons may respond to baroreflex activation and that adrenergic neurons may be involved in blood pressure regulation.
在有或没有单侧颈动脉结扎的正常血压Wistar-Kyoto大鼠（WKY）和自发性高血压大鼠（SHR）中，检测了脑干C1和C2区域的苯乙醇胺N-甲基转移酶（PNMT）活性。SHR中的PNMT活性显著高于WKY（P小于0.01）。与结扎侧相比，WKY和SHR未结扎侧C1和C2区域的PNMT活性均显著升高。这些结果表明，肾上腺素能神经元中PNMT的活性可能对压力反射激活有反应，并且肾上腺素能神经元可能参与血压调节。
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