美吡拉敏对清醒大鼠脑葡萄糖利用的区域效应。

Regional effect of mepyramine on cerebral glucose utilization in conscious rats.

作者信息

Gross P M, Harper A M, Teasdale G H

出版信息

Eur J Pharmacol. 1982 Feb 5;77(4):347-50. doi: 10.1016/0014-2999(82)90142-x.

Abstract

We examined effects of the antihistamine, mepyramine, which occupies cerebral H1-receptors, on regional brain metabolism of glucose in conscious rats. Although glucose utilization by most structures was not significantly affected, in high doses, mepyramine did cause modest, localized reductions in brain areas with both high (ventromedial nucleus of hypothalamus) and low (medial forebrain bundle) densities of histamine H1-receptors.

摘要

我们研究了占据脑H1受体的抗组胺药美吡拉敏对清醒大鼠脑局部葡萄糖代谢的影响。虽然大多数结构的葡萄糖利用未受到显著影响，但高剂量的美吡拉敏确实在组胺H1受体密度高（下丘脑腹内侧核）和低（内侧前脑束）的脑区引起了适度的、局部性的降低。