Mchedlishvili G I, Sikharulidze N V, Itkis M L, Ianushevskiĭ S
Fiziol Zh SSSR Im I M Sechenova. 1982 Jan;68(1):64-71.
In rabbit chest-head preparation with largely exposed brain, the cerebral volume (CV) and the cerebral blood volume (CBV) were continuously recorded number conditions of controlled alterations of the systemic arterial and venous pressures (SAP and SVP resp.). The obtained relationships were linear and described by the equations as follows: delta CV = 0.0028 SAP; delta CBV = 0.0013 SAP; delta CV = 0.028 SVP; delta CBV = 0.013 SVP; they show the effect of the SVP changes to be nearly ten times greater than that of the SAP. Half of the increase in CV was caused by the CBV increase and the other half - by tissue hydration under particular conditions of the experiments. The data obtained bear on the effects of the systemic circulation on brain oedema development.
