Boulton A J, Scarpello J H, Ward J D
Diabetologia. 1982 Jan;22(1):6-8. doi: 10.1007/BF00253861.
Venous PO2 was measured in the feet and hands of four subject groups: 14 diabetics with neuropathy and foot ulceration; 12 diabetics with neuropathy but no ulceration; 11 diabetics with no evidence of microvascular complications; and 10 non-diabetic controls. Neither patients nor controls had clinical evidence of peripheral vascular disease. The mean venous PO2 in the feet of subjects with neuropathy and foot ulceration was significantly higher than in controls or the other two diabetic groups. Venous PO2 in the feet of the subjects with ulcers was also significantly higher than in their hands or in the hands of the other groups. These results provide further evidence of abnormal blood flow in the diabetic neuropathic foot and are compatible with arteriovenous shunting.
14例患有神经病变和足部溃疡的糖尿病患者；12例患有神经病变但无溃疡的糖尿病患者；11例无微血管并发症迹象的糖尿病患者；以及10名非糖尿病对照者。患者和对照者均无外周血管疾病的临床证据。患有神经病变和足部溃疡的受试者足部的平均静脉血氧分压显著高于对照组或其他两组糖尿病患者。溃疡患者足部的静脉血氧分压也显著高于其手部或其他组的手部。这些结果进一步证明了糖尿病神经病变足部存在异常血流，并且与动静脉分流相符。
