Uher F, Dobronyi I, Gergely J
Immunology. 1982 Feb;45(2):387-93.
The primary receptor ligand interaction between rat leucocyte membrane receptors for IgM and their ligands were examined. We found that the incubation time for optimal IgM binding is different on the two types of IgM-Fc receptor-bearing spleen cells and peritoneal macrophages. The investigation of cytophilic activity of polyclonal or monoclonal IgM proteins and their fragments from various species indicated the fine specificity of receptors. Finally, data are presented which suggest a multiple point co-operative binding between IgM-coated erythrocytes and IgM-Fc receptor-bearing cells.
对大鼠IgM的白细胞膜受体与其配体之间的主要受体 - 配体相互作用进行了研究。我们发现，在两种带有IgM - Fc受体的脾细胞和腹腔巨噬细胞上，最佳IgM结合的孵育时间是不同的。对来自不同物种的多克隆或单克隆IgM蛋白及其片段的亲细胞活性研究表明了受体的精细特异性。最后，给出的数据表明IgM包被的红细胞与带有IgM - Fc受体的细胞之间存在多点协同结合。
