Medgyesi G A, Fóris G, Dezsö B, Gergely J, Bazin H
Immunology. 1980 Jul;40(3):317-23.
Macrophage-cytophilic antibody activity of various immunoglobulin classes and subclasses was tested in two different rosetting systems. Cytophilic antibody activity of IgM, IgG2a and IgG1 was verified in the SRBC system, while IgM, IgG2a and IgG2c were found to be active in the trypanosome system. Sensitivity to cytochalasin B treatment of SRBC rosette formation was dependent on the class of antibody and decreased in the following order: IgM > IgG1 > IgG2a. Trypanosome rosette formation was prevented by the same drug regardless the type of antibody. Vinblastin caused an enhancement of rosette formation in the SRBC system in low concentration, except when the antibody belonged to subclass IgG1. The enhancing effect was less pronounced in the trypanosome system.
在两种不同的玫瑰花结形成系统中检测了各种免疫球蛋白类别和亚类的巨噬细胞嗜细胞抗体活性。在绵羊红细胞（SRBC）系统中证实了IgM、IgG2a和IgG1的嗜细胞抗体活性，而在锥虫系统中发现IgM、IgG2a和IgG2c具有活性。SRBC玫瑰花结形成对细胞松弛素B处理的敏感性取决于抗体类别，其敏感性按以下顺序降低：IgM＞IgG1＞IgG2a。无论抗体类型如何，相同药物均可阻止锥虫玫瑰花结的形成。长春碱在低浓度时可增强SRBC系统中的玫瑰花结形成，但抗体属于IgG1亚类时除外。在锥虫系统中，这种增强作用不太明显。
