Gal T J, Arora N S
J Appl Physiol Respir Environ Exerc Physiol. 1982 Jan;52(1):57-63. doi: 10.1152/jappl.1982.52.1.57.
Respiratory mechanics were studied in six supine conscious volunteers during progressive muscle weakness produced by infusion of d-tubocurarine. Partial curarization was carried out to the point of abolishing head lift ability and handgrip strength. At all levels of partial paralysis, expiratory muscle strength was significantly more impaired than inspiratory strength. Despite this, subjects maintained relatively normal maximal expiratory flow rates, whereas inspiratory flows decreased significantly. The diminished inspiratory flows are not fully explained by decreased driving pressures during force inspiration, since inspiratory resistance increased significantly with the decreased flow. Inspiratory flow patterns suggest a variable extrathoracic obstruction most likely due to the absence of normal airway abductor activity during inspiration. Maximal respiratory muscle weakness decreased forced vital capacity by 29% and total lung capacity by 15%. The decreased level of lung inflation did not alter lung elastic recoil. Functional residual capacity was unchanged, but inspiratory capacity decreased by 25% and residual volume increased by 38%. These changes are in accord with predictions based on the decreased muscle strength and normal respiratory system recoil.
在六名清醒仰卧位志愿者中，通过输注d - 筒箭毒碱诱导进行性肌无力时，对呼吸力学进行了研究。进行部分箭毒化，直至消除抬头能力和握力。在部分麻痹的各个阶段，呼气肌力量受损程度明显大于吸气肌力量。尽管如此，受试者仍保持相对正常的最大呼气流量，而吸气流量则显著下降。用力吸气时驱动压力降低并不能完全解释吸气流量的减少，因为吸气阻力随着流量降低而显著增加。吸气流量模式提示存在可变的胸外梗阻，这很可能是由于吸气时缺乏正常的气道外展肌活动所致。最大呼吸肌无力使用力肺活量降低29%，肺总量降低15%。肺充气水平降低并未改变肺弹性回缩力。功能残气量未变，但吸气量降低25%，残气量增加38%。这些变化与基于肌肉力量降低和呼吸系统正常回缩力的预测结果一致。
