Ali H H, Wilson R S, Savarese J J, Kitz R J
Br J Anaesth. 1975 May;47(5):570-4. doi: 10.1093/bja/47.5.570.
The effect of tubocurarine on the respiratory function of conscious, non-medicated volunteers was correlated with the degree of neuromuscular blockade measured with the train-of-four technique (the evoked response of the adductor pollicis brevis muscle to trains of four supramaximal ulnar nerve stimuli at 2 Hz, repeated once every 10 sec). Respiratory frequency, tidal volume, vital capacity, inspiratory force and peak expiratory flow rate were measured, (a) before administration of tubocurarine, (b) when the ratio of the amplitude of the fourth response to the amplitude of the first response of the train-of-four reached 60%, and (c) during recovery of the ratio until the control (100%) value was reached. Respiratory frequency, tidal volume and peak expiratory flow rate were not altered. Vital capacity and inspiratory force were both reduced significantly at the 60% level and the former also at the 70% level when compared with the control. The magnitude of change in all variables is of minor clinical importance, however, since the lowest measured values are well above acceptable minimum limits required for adequate respiratory function.
筒箭毒碱对清醒、未用药志愿者呼吸功能的影响与采用四个成串刺激技术（拇短收肌对以2赫兹频率施加的四个超强尺神经刺激串的诱发反应，每10秒重复一次）所测得的神经肌肉阻滞程度相关。测量了呼吸频率、潮气量、肺活量、吸气力和呼气峰值流速，(a) 在给予筒箭毒碱之前，(b) 当四个成串刺激中第四个反应的幅度与第一个反应的幅度之比达到60%时，以及(c) 在该比值恢复到对照（100%）值的过程中。呼吸频率、潮气量和呼气峰值流速未发生改变。与对照相比，肺活量和吸气力在60%水平时均显著降低，前者在70%水平时也显著降低。然而，所有变量的变化幅度在临床上并不重要，因为所测得的最低值远高于充分呼吸功能所需的可接受最低限度。
