Suzuki S, Sasaki H, Sekizawa K, Takishima T
J Appl Physiol Respir Environ Exerc Physiol. 1982 Feb;52(2):295-303. doi: 10.1152/jappl.1982.52.2.295.
From excised dog lungs we isolated airtight the intrapulmonary main bronchi (5-6 cm in length) with beads according to the technique described by Takishima et al. (J. Appl. Physiol. 38: 875-881, 1975), except for the most distal bronchus in which a retrograde catheter was inserted into the pleural surface of the lung. Air flowed from the retrograde catheter to the isolated main lobar bronchi at a given transpulmonary pressure (PL) with variable dynamic rates of driving pressure. We studied isovolume pressure-flow (IVPF) curves in the isolated intrapulmonary bronchi. The IVPF curves showed maximum expiratory flow (Vmax) and negative effort dependence. Vmax increased with increased PL and with increased dynamic rate of driving pressure and decreased with increased peripheral airway resistance added to the retrograde catheter. Bronchograms showed that dynamic compression occurred near the outlet of the isolated bronchi. When the isolated bronchi were dissected free from the surrounding parenchyma, Vmax decreased by 20-30% compared with Vmax in intact bronchi. We concluded that Vmax in intrapulmonary bronchi is preserved by mechanical interdependence between bronchi and parenchyma.
根据Takishima等人（《应用生理学杂志》38: 875 - 881, 1975）所描述的技术，我们从切除的犬肺中，用珠子将肺内主支气管（长度为5 - 6厘米）气密隔离，最远端的支气管除外，在该支气管中，一根逆行导管插入到肺的胸膜表面。在给定的跨肺压（PL）下，空气以可变的驱动压力动态速率从逆行导管流向隔离的主叶支气管。我们研究了隔离的肺内支气管的等容压力 - 流量（IVPF）曲线。IVPF曲线显示出最大呼气流量（Vmax）和负用力依赖性。Vmax随着PL的增加、驱动压力动态速率的增加而增加，并随着添加到逆行导管的外周气道阻力增加而降低。支气管造影显示，动态压缩发生在隔离支气管的出口附近。当将隔离的支气管从周围实质中游离出来时，与完整支气管中的Vmax相比，Vmax降低了20 - 30%。我们得出结论，肺内支气管中的Vmax通过支气管与实质之间的机械相互依存关系得以保留。
