Dyer A R, Stamler J, Shekelle R B, Schoenberger J A, Stamler R, Shekelle S, Berkson D M, Paul O, Lepper M H, Lindberg H A
J Chronic Dis. 1982;35(4):275-82. doi: 10.1016/0021-9681(82)90083-2.
This report, the second in a series on pulse pressure and pure systolic hypertension, examined in prospective analyses the associations between both the initial values of five variables and the changes in these variables and pulse pressure, utilizing data from three Chicago epidemiologic studies, in order to determine whether variables known to be related to blood pressure and hypertension are related to pure systolic hypertension or 'classical' hypertension. In these analyses follow-up pulse pressure, which was measured from 2-5 years after the initial measurement of the other variables, was redefined so that the association between the initial value or change and pulse pressure indicated whether the initial value or change was more strongly related to follow-up systolic or diastolic blood pressure. In these three studies, only the initial value for cigarette use had a consistent positive association with follow-up pulse pressure. Change in heart rate was generally positively related to follow-up pulse pressure, while the initial value was not. For relative weight and serum cholesterol, both the change and the initial tended to be negatively related. For glucose, the association was not consistent for either the initial value or the change. The results from these prospective analyses thus suggest that cigarette use is related to pure systolic hypertension, rather than 'classical' hypertension.
本报告是关于脉压和单纯收缩期高血压系列报告中的第二篇，利用来自芝加哥三项流行病学研究的数据，在前瞻性分析中研究了五个变量的初始值以及这些变量的变化与脉压之间的关联，以确定已知与血压和高血压相关的变量是否与单纯收缩期高血压或“经典”高血压有关。在这些分析中，随访脉压是在首次测量其他变量2至5年后测量的，对其进行了重新定义，以便初始值或变化与脉压之间的关联表明初始值或变化与随访收缩压或舒张压的关系更为密切。在这三项研究中，只有吸烟的初始值与随访脉压始终呈正相关。心率变化通常与随访脉压呈正相关，而初始值则不然。对于相对体重和血清胆固醇，变化和初始值都倾向于呈负相关。对于血糖，初始值或变化的关联都不一致。因此，这些前瞻性分析的结果表明，吸烟与单纯收缩期高血压有关，而非“经典”高血压。
