O'Dorisio T M, Falko J M, Cataland S, Almoney R W, George J M, Mazzaferri E L, Reynolds J C
J Clin Endocrinol Metab. 1982 Apr;54(4):798-802. doi: 10.1210/jcem-54-4-798.
The serum gastrin response to a standard test meal was evaluated in patients with familial medullary thyroid carcinoma (MTC) and in normal subjects. Patients with MTC and elevated plasma calcitonin levels had a lower gastrin response to the test meal than did normal persons or MTC patients who had normal calcitonin levels postthyroidectomy. There was no significant difference between the mean gastrin response of the normal group and that of the MTC patients with normal calcitonin levels. The serum gastrin response was studied before and after thyroidectomy in four patients. In all four, the post-operative response was greater than the preoperative one . We conclude that patients with MTC may have reduced gastrin responses to a test meal. This effect may be related to circulating calcitonin, somatostatin, or other factors related to familial MTC.
对患有家族性甲状腺髓样癌（MTC）的患者和正常受试者进行了血清胃泌素对标准试验餐的反应评估。患有MTC且血浆降钙素水平升高的患者对试验餐的胃泌素反应低于正常人或甲状腺切除术后降钙素水平正常的MTC患者。正常组与降钙素水平正常的MTC患者的平均胃泌素反应之间无显著差异。对4例患者在甲状腺切除术前和术后进行了血清胃泌素反应研究。在所有4例患者中，术后反应均大于术前反应。我们得出结论，MTC患者对试验餐的胃泌素反应可能降低。这种效应可能与循环中的降钙素、生长抑素或与家族性MTC相关的其他因素有关。
