Miyauchi A, Morimoto S, Onishi T, Takai S, Okada Y, Himeno S, Kosaki G, Kumahara Y
Endocrinol Jpn. 1980 Apr;27(2):153-6. doi: 10.1507/endocrj1954.27.153.
In 3 patients with medullary thyroid carcinoma, plasma calcitonin levels showed 3 distinct peaks associated with a simultaneous rise in plasma gastrin after each meal. It is suggested that endogenous gastrin secreted following food intake stimulated the calcitonin secretion from the tumor. The peak of the plasma calcitonin secretion after the evening meal was less prominent than that for breakfast or lunch, while no significant differences were observed in peak values in plasma gastrin after each meal. The reason for this discrepancy remains to be clarified.
在3例甲状腺髓样癌患者中，血浆降钙素水平出现3个明显的峰值，且每次进餐后血浆胃泌素同时升高。提示进食后分泌的内源性胃泌素刺激了肿瘤降钙素的分泌。晚餐后血浆降钙素分泌的峰值不如早餐或午餐时明显，而每餐餐后血浆胃泌素峰值未观察到显著差异。这种差异的原因尚待阐明。
